If you have had gout, do not eat a large amount of meat and seafood at a barbecue or a group meal, and drink less alcohol
Among people who have had gout, higher purine intake over the preceding 2 days is associated with more flares, with the highest-intake group most affected. This also holds among those taking urate-lowering drugs. Drinking 2–4 alcoholic drinks the day before is also linked to more flares, whether beer, spirits or wine.
No cost. At a barbecue or a group meal, order fewer meat s…
A study followed 633 gout patients online for 1 year, comparing a pair of days before each person's flare with…
No cost. At a barbecue or a group meal, order fewer meat skewers and less seafood, and drink less. The hard part is holding yourself at the table.
A study followed 633 gout patients online for 1 year, comparing a pair of days before each person's flare with a pair of their own days when they did not flare (a case-crossover study). Purine is a component of food that the body turns into uric acid. Splitting the purine total over that pair of days from low to high into bands, and comparing with the lowest band, flares were more common with higher intake, and the odds ratios in the four higher bands were 1.17, 1.38, 2.21, and 4.76 (OR, trend P<0.001). Counting only purine from animal sources, the odds ratios were 1.42, 1.34, 1.77, and 2.41. Counting only purine from plant sources, they were 1.12, 0.99, 1.32, and 1.39. Split by sex, by whether the person drank, and by whether they took a diuretic, allopurinol, an anti-inflammatory pain drug, or colchicine, the result was the same. Another study by the same researchers looked at alcohol in the 24 hours before a flare in 724 gout patients. Compared with not drinking, the odds ratio for more than 1 and up to 2 drinks was 1.36 (95% CI 1.00–1.88, confidence interval), and for more than 2 and up to 4 drinks it was 1.51 (1.09–2.09). Wine, beer, and spirits were each linked to flares. For people who have not had gout, another follow-up study applies: 47150 men in the United States followed for 12 years, recorded only, not assigned to groups. The top fifth by meat intake had about a 41% higher risk of gout than the bottom fifth (relative risk RR 1.41, 1.07–1.86). Seafood was about 51% higher (1.51, 1.17–1.95). The top fifth by dairy intake was instead about 44% lower (0.56, 0.42–0.74). Vegetables high in purine, and total protein, showed no link. In the same men, an extra 12-ounce bottle of beer a day (about 355 ml) raised risk by about 49% (1.49, 1.32–1.70). A daily drink of spirits raised it by about 15% (1.15, 1.04–1.28). Wine showed no statistical difference (1.04, 0.88–1.22)
Zhang Y, Chen C, Choi H, Chaisson C, Hunter D, Niu J, Neogi T (2012). Purine-rich foods intake and recurrent gout attacks. Annals of the Rheumatic Diseases, 71(9), 1448-1453. https://doi.org/10.1136/annrheumdis-2011-201215;Neogi T, Chen C, Niu J, Chaisson C, Hunter DJ, Zhang Y (2014). Alcohol quantity and type on risk of recurrent gout attacks: an internet-based case-crossover study. The American Journal of Medicine, 127(4), 311-318. https://doi.org/10.1016/j.amjmed.2013.12.019;Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G (2004). Purine-rich foods, dairy and protein intake, and the risk of gout in men. New England Journal of Medicine, 350(11), 1093-1103. https://doi.org/10.1056/NEJMoa035700;Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G (2004). Alcohol intake and risk of incident gout in men: a prospective study. Lancet, 363(9417), 1277-1281. https://doi.org/10.1016/S0140-6736(04)16000-5;Major TJ, Topless RK, Dalbeth N, Merriman TR (2018). Evaluation of the diet wide contribution to serum urate levels: meta-analysis of population based cohorts. BMJ, 363, k3951. https://doi.org/10.1136/bmj.k3951
Open source linkWritten mainly for people who have already had a flare. For people who have not had gout, what you eat moves uric acid less than most people think. Among 16760 white adults in the United States without gout, diet could explain no more than 0.3% of the difference in serum uric acid, while common genetic differences could explain 23.9%. So when someone nearby gets gout after barbecue and beer, diet is a trigger and constitution accounts for more. The studies looked at how much meat, seafood, and alcohol was eaten, not at whether it was grilled; cold seafood with beer counts the same. All of the studies only followed and recorded, with no assignment to groups; what was eaten at the time of a flare was reported by the patients online, the people studied were American, and no Chinese data were found. The dairy figure is also only a follow-up record; no trial has shown that drinking more milk prevents gout. Eating less cannot replace a urate-lowering drug, and cutting foods lowers uric acid only so much; see item 9 (once gout is diagnosed, take a urate-lowering drug long term). The mortality account for processed meat and alcohol is in section 2, item 18 (eat less processed meat) and section 2, item 19 (drink little or no alcohol)