Chapter 34 / 14 tips

Do not let medicines kept at home cause serious harm

Fever reducers, painkillers, cold medicines, stomach medicines, and anti-diarrhea medicines: many of them can be bought at a pharmacy with no prescription. Being able to buy them with no prescription does not mean any way of taking them is fine. This section does not say which medicine to take for each illness. It only picks a few actions that each avoid a serious outcome. All items in this section are classified under the mortality measure. Most examine serious outcomes such as liver failure, stomach bleeding, and newborn kidney failure; a few examine headaches or reactions while driving. Most of the benefit is one fewer serious accident. Studies do not give a figure for how much doing it would cut the risk. The size of the benefit is judged by how heavy the outcome is, and each note says why it was set that way. What is already written elsewhere is only pointed to here. If a medicine or a cleaning product is swallowed by mistake, see section 13, item 20 (accidental ingestion). For taking a chronic-disease medicine in full as the doctor ordered, see section 16, item 1 (finish the medicine as prescribed). For buying a prescription drug online, the prescription has to be checked first, see section 28, item 6 (get weight-loss drugs with a hospital prescription). The people these items benefit are you and your family, the top two tiers.

English, Russian and Spanish use dlgrv’s unofficial translations. Newly revised entries appear in the Chinese original until a checked translation is available. The author’s latest Chinese text is authoritative. Translation revision: dlgrv/HowToLiveBetter · b25fa8a

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01Evidence B

Before taking two cold medicines or painkillers at the same time, read the ingredient list, keep acetaminophen in a single product, and go to the hospital the same day if you took too much even without feeling ill

Many cold medicines contain acetaminophen. Taking medicines from 2 different packs that both contain it means a double dose, and too much harms the liver. In the United States, among people whose liver failed suddenly because of it, nearly 3 in 10 died before they could get a new liver. Leaflets in China advise at most 2 grams a day. The United States also warns against 3 or more drinks of alcohol a day while taking it. If you took too much, go to the hospital right away even if you feel fine. The antidote works better the sooner it is used.

Cost

No cost at all. It only takes a minute or two to glance at…

Benefit

Over 6 years, 22 hospitals in the United States registered 662 cases of acute liver failure in a row. Of these…

02Evidence B

Do not treat a child's fever with aspirin, nimesulide, or metamizole, do not give a minor a cold medicine that contains metamizole, and measure liquid fever medicine with the dosing device in the box

Aspirin is linked to Reye's syndrome, an illness that harms the brain and the liver, and about 3 in 10 children in US surveillance died. In China, nimesulide is forbidden under 12 and metamizole under 18. Measure liquid fever medicine with the dosing device that comes in the box. Spoons at home differ a lot in size. Drops and the drinkable liquid may not be the same strength. The US example differs by 3 times. If you switch the form, do not feed the old number of milliliters.

Cost

No cost involved. Simply check the generic name and ingred…

Benefit

Reye's syndrome causes brain disease and fatty change in the liver, and it usually appears after influenza or…

03Evidence A

If you are 60 or older, have had stomach bleeding, or take anticoagulants or steroids, ask a doctor before using painkillers such as ibuprofen

Painkillers such as ibuprofen, naproxen, and aspirin can harm the stomach. In the high-dose trials, people taking ibuprofen had about 4 times the risk of stomach bleeding or a hole in the stomach wall, compared with people not taking it. The risk is higher for older people, people who have had stomach bleeding, people who are also taking a blood thinner or a steroid drug, and people who drink 3 or more drinks of alcohol a day.

Cost

No cost involved. Simply ask a doctor or pharmacist.

Benefit

These medications are classified as nonsteroidal anti-inflammatory drugs (NSAIDs);

04Evidence B

For children under 2 with colds, don’t give them over-the-counter multi-ingredient cold and cough medicines on your own

The National Medical Products Administration requires a warning on 14 kinds of combination cold medicines for children. The warning says it does not recommend that a parent give the medicine to a child under 2 on their own. It should be used with a doctor or a pharmacist guiding it. In trials done on children, cough medicines and anti-allergy medicines worked no better than a placebo (a dummy pill).

Cost

There is no cost at all;

Benefit

In its Announcement No. 57 of 2021, the National Medical Products Administration updated the instructions for…

05Evidence B

Pregnancy after 20 weeks: avoid taking ibuprofen and similar painkillers on your own

Taking a drug like ibuprofen after 20 weeks of pregnancy can harm the kidneys of the fetus and leave less fluid around the baby. Among reports of this kind received in the United States, there were cases in which the newborn died. Low-dose aspirin prescribed by a doctor is not included.

Cost

No cost involved.

Benefit

In October 2020, the U.S. Food and Drug Administration (FDA) issued a safety warning. Use of nonsteroidal anti…

06Evidence B

Buying omeprazole over the counter for heartburn and acid reflux — use it for no more than 7 days; see a doctor immediately if you have trouble swallowing, vomit blood, or pass black stools

Since 2022, omeprazole enteric-coated tablets have been available over the counter without a prescription. However, the package instructions clearly state that you should only take it for up to 7 days, and avoid using it again within two months. If you experience trouble swallowing, pain in the throat, vomit blood, or pass black stools, do not take it on your own — these are potential signs of serious medical conditions. This medication can also mask symptoms of stomach cancer, potentially delaying an accurate diagnosis.

Cost

No cost involved — just follow the dosage instructions on…

Benefit

Announcement No. 68 of 2022 from the National Medical Products Administration switched omeprazole enteric-coat…

07Evidence A

Don’t ask doctors for antibiotics for the common cold

Taking antibiotics for a cold doesn’t speed up recovery compared to not taking them at all. For adults, the risk of side effects is more than twice as high when using antibiotics. For cases where nasal discharge with pus lasts less than 10 days, there is no clear benefit to taking antibiotics either.

Cost

It costs nothing and can even save you money on medicine.

Benefit

A Cochrane systematic review pooled data from 6 randomized trials involving 1,147 participants. When comparing…

08Evidence A

For diarrhea, start by drinking oral rehydration solution; do not give anti-diarrheal drugs to children under 5

The most important thing during diarrhea is rehydration, not stopping the diarrhea itself. Mix the solution exactly as directed on the package and drink it — never substitute it with sugary juices or soft drinks, as the excess sugar can actually worsen dehydration. Never give anti-diarrheal medications such as loperamide to kids under 5 years old; in severe cases these drugs can cause life-threatening intestinal blockages.

Cost

A box of oral rehydration solution costs just a few dollar…

Benefit

The diarrhea-treatment manual of the World Health Organization (WHO) states that "anti-diarrhea" drugs and ant…

09Evidence B

For headaches, do not take simple painkillers for 15 days a month or combination pills for 10 days, or the medication may be causing the pain

If headaches keep coming and you take a painkiller every day, you may hurt more the more you take. The international headache classification calls this a medication-overuse headache, a headache brought on by the medicine itself. Headache on 15 or more days in a month, plus an ordinary painkiller on 15 or more days or a combination painkiller on 10 or more days, running past 3 months, is enough for the diagnosis. Most people improve after they stop the medicine they were taking too much of.

Cost

No direct cost. You’ll just need to keep track of how many…

Benefit

The 3rd edition of the International Classification of Headache Disorders, from the International Headache Soc…

10Evidence B

Clear out expired and unused medicines regularly; dispose of them with packaging in hazardous-waste bins, not at home

In the United States, of the medicines a child swallowed without an adult watching, nearly half were prescription tablets. Of those prescription medicines, about 3 in 10 belonged to a grandparent. Clearing out medicines you will not use removes something a child can find. Put the cleared-out medicine, packaging and all, into the hazardous-waste bin, or hand it to a pharmacy that takes old medicines.

Cost

No cost. Sort the medicine cabinet once a year — about ten…

Benefit

US emergency-department surveillance estimates that from 2004 to 2013, children under 6 who swallowed a medici…

11Evidence B

While taking cephalosporins, metronidazole, and similar antibacterials, and for 7 days after stopping, avoid alcohol — including alcohol in Huoxiang Zhengqi oral liquid and cough syrups

Some cephalosporins, and drugs such as metronidazole, make the face flush and bring on sweating and a racing heart if they meet alcohol. A severe case brings trouble breathing and a drop in blood pressure. It is not only liquor and beer. An alcohol-containing medicine such as Huoxiang Zhengqi oral liquid (藿香正气水, a Chinese medicine liquid that contains alcohol) or cough syrup can do it too. Do not touch alcohol from the time you are taking the drug through 7 days after you stop.

Cost

No money. Abstain from alcohol for a little over a week;

Benefit

This is called a disulfiram-like reaction. A 2023 medication-safety article from the Fujian drug regulator say…

12Evidence B

After a cold medicine or an anti-allergy medicine that contains chlorphenamine (also called chlorpheniramine) or diphenhydramine, do not drive while you are taking it, and do not work at a height or operate a machine

Many combination cold medicines mix in an anti-allergy ingredient such as chlorphenamine or diphenhydramine, and taking it makes you drowsy. The national drug regulator says that while you are taking this kind of drug, do not drive, do not work at a height, and do not operate a machine. On a driving simulator, people who had taken diphenhydramine drove worse than people who had drunk alcohol. Feeling that you are not drowsy does not mean the driving is fine.

Cost

No money. Glance at the ingredient list when you buy the m…

Benefit

A 2010 adverse-reaction bulletin from the National Medical Products Administration says that vitamin C Yinqiao…

13Evidence B

If you take medicines such as cholesterol or blood-pressure drugs long term, check the leaflet for grapefruit; if listed, avoid grapefruit, pomelo, and grapefruit juice

Grapefruit can raise some drug levels in the blood severalfold: the dose has not changed, but it is like taking too much. One grapefruit or one glass of juice can do this, and some effect remains even if the medicine is taken a day later. Severe effects may injure muscles or kidneys or cause an arrhythmia that can lead to sudden death. Pomelo can do the same; ordinary sweet oranges do not.

Cost

No cost. When receiving a long-term medicine, read “Drug i…

Benefit

A 2013 review by Canadian pharmacologists reported more than 85 drugs known or predicted to interact with grap…

14Evidence B

If you have chronic kidney disease or impaired kidney function, ask a doctor before buying painkillers such as ibuprofen for long-term use; also avoid star fruit and its juice

People with impaired kidney function are more susceptible to acute kidney injury when taking painkillers such as ibuprofen. Unsupervised long-term use is also associated with kidney failure. Adding these drugs to a diuretic plus an ACE inhibitor or ARB is associated with about 30% more acute kidney injury. Star fruit can cause persistent hiccups, confusion, and seizures in people with kidney problems; about 30% of the reported poisoning cases in this group were fatal.

Cost

No cost. Ask a doctor or pharmacist before buying a painki…

Benefit

These painkillers are called nonsteroidal anti-inflammatory drugs (NSAIDs), commonly including ibuprofen, napr…

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